Tuesday 13th March 2018
Professor Serena M Best:
Repairing Tissues in the Human Body - Pores for Thought the Human Body – “Pores for Thought”
Some of the first attempts to repair human tissue were reported as early as 1600 BC. These were relatively primitive attempts to replace bone damaged by injury or disease. Over time, the materials of choice have gradually changed from those that simply offer mechanical support to those that interact directly with the biological environment. There is now considerable interest in the delivery of biological cells to assist in the repair process and there is a need for the design of porous biomaterial “scaffolds” to achieve this. For cells to be able to migrate through a scaffold, there must be holes in the structure with appropriate dimensions. This talk will consider two scaffold materials, a material which is similar in composition to the mineral component of bone (hydroxyapatite) and collagen, a highly versatile and bioactive natural macromolecule. To optimise the repair process using these scaffolds, it is important to understand the influences on cell behaviour, of the structure and orientation of the pores in the scaffold, and the interconnections between them. Choice of scaffold surface biochemistry also allows us to balance scaffold “activity” and mechanical performance. This talk will cover the recent work undertaken to study the structure and properties of scaffolds for a range of clinical applications in soft and hard tissue repair.
Tuesday 13th March 2018 at 7pm at Coseners House Hotel, Garden Room
the Human Body – “Pores for Thought”
Serena Best is a Professor of Materials Science and Fellow of St. John’s College, Cambridge. She co-directs the Cambridge Centre for Medical Materials (along with Professor Ruth Cameron). She has published around 300 journal papers, books and book chapters, she holds 9 patents in the fields of biomaterials and skeletal repair and has played a part in the spin out of two companies associated with this work. She is a Fellow of the Royal Academy of Engineering and also the Institute of Materials, Minerals and Mining and is Senior Vice President of the Institute. She was awarded a CBE in the Queen’s Birthday Honours List in 2017 for services to Biomaterials Engineering.